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pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can lower panobinostat concentrations by ~70% and bring about therapy failure.pentobarbital will decrease the level or influence of ethotoin by influencing hepatic enzyme CYP2C9/ten metabolism. Use Warning/